Two new furanoditerpenes from Saururus chinenesis and their effects on the activation of peroxisome proliferator-activated receptor gamma

J Nat Prod. 2002 Apr;65(4):616-7. doi: 10.1021/np010440j.

Abstract

Two new acyclic furanoditerpene compounds, saurufuran A (1) and B (2), were obtained from the root of Saururus chinensis, and their structures were elucidated by means of 1D and 2D NMR spectroscopic analyses. Saurufuran A (1) is effective on the activation of peroxisome proliferator-activated receptor gamma (PPARgamma) with an EC(50) value of 16.7 microM; however, saurufuran B (2), with an EC(50) value of >100 microM, weakly activated the PPARgamma.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3T3 Cells / drug effects
  • Animals
  • Cells, Cultured / drug effects
  • Diterpenes / chemistry
  • Diterpenes / isolation & purification*
  • Diterpenes / pharmacology
  • Furans / chemistry
  • Furans / isolation & purification*
  • Furans / pharmacology
  • Humans
  • Korea
  • Ligands
  • Luciferases / metabolism
  • Mice
  • Molecular Conformation
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Plant Roots / chemistry
  • Plants, Medicinal / chemistry*
  • Receptors, Cytoplasmic and Nuclear / agonists*
  • Transcription Factors / agonists*
  • Transfection
  • beta-Galactosidase / metabolism

Substances

  • Diterpenes
  • Furans
  • Ligands
  • Receptors, Cytoplasmic and Nuclear
  • Transcription Factors
  • saurufuran A
  • saurufuran B
  • Luciferases
  • beta-Galactosidase